New Challenges in (Bio)Analytical Sample Treatment Procedures for Clinical Applications

The primary cause of poor and ambiguous results obtained from the bioanalytical process is sample pre-treatment, especially in clinical analysis because it involves dealing with complex matrices, such as whole blood, urine, saliva, serum, plasma. So, aim this review to focus attention on classical new techniques pre-treatment for biological samples used process. We discussed methods generally these types samples. Undoubtedly, a daunting task deal analyst may encounter substantial loss analytes interest, or overall be too time-consuming. Nowadays, we are inclined use green solvents environment, but without sacrificing analytical performance selectivity. All characteristics mentioned above should added difficulty withdrawal like blood can an invasive practice. For reasons, now also find literature saliva alternative that do not require fabric phase sorptive extraction (FPSE). text has been divided into following two distinct parts: firstly, described applications under different subsections, anticancer drugs, antibiotics, vitamins, antivirals, non-steroidal anti-inflammatory statin, imidazoles, triazoles. second part dedicated preparation diagnostic purposes techniques: solid-phase microextraction (SPME), by packed sorbent (MEPS), dispersive liquid–liquid (DDLME),